Sphingosine kinase 1 and tumor.
- Author:
Cai-Xia ZHANG
1
;
Hong-Wei HE
;
Rong-Guang SHAO
Author Information
1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Amino Alcohols;
pharmacology;
Animals;
Apoptosis;
drug effects;
Cell Movement;
drug effects;
Cell Proliferation;
drug effects;
Ceramides;
metabolism;
Enzyme Activation;
Enzyme Inhibitors;
pharmacology;
Humans;
Lysophospholipids;
metabolism;
Neoplasms;
metabolism;
pathology;
Neovascularization, Pathologic;
Phosphorylation;
Phosphotransferases (Alcohol Group Acceptor);
antagonists & inhibitors;
metabolism;
Sphingosine;
analogs & derivatives;
metabolism;
Thiazoles;
pharmacology
- From:
Acta Pharmaceutica Sinica
2013;48(7):971-978
- CountryChina
- Language:Chinese
-
Abstract:
Sphingolipids as an important regulator play a critical role in the cell biological functions. Among them, ceramide (Cer) and sphingosine (Sph) induce apoptosis and inhibit cell proliferation; on the contrary sphingosine 1-phosphate (S1P) promotes cell survival and proliferation. The balance between ceramide/sphingosine and S1P forms a so-called "sphingolipid-rheostat", which decides the cell fate. Sphingosine kinases, which catalyze the phosphorylation of sphingosine to S1P, are critical regulators of this balance. Here, we review the role of sphingosine kinase 1 (SphK1) in regulating fundamental biological processes and tumorigenesis and the potential of SphK1 as a new target for cancer therapeutics.
