Application of efficient synthetic techniques in drug research.
- Author:
Yu ZHOU
1
;
Lei ZHANG
;
Zeng LI
;
Hong LIU
Author Information
1. State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
- Publication Type:Journal Article
- MeSH:
Click Chemistry;
Combinatorial Chemistry Techniques;
methods;
Drug Discovery;
methods;
Microwaves;
Pharmaceutical Preparations;
chemical synthesis
- From:
Acta Pharmaceutica Sinica
2013;48(7):1014-1030
- CountryChina
- Language:Chinese
-
Abstract:
Compound libraries and chemical synthesis play important roles in drug discovery and development, and efficient synthetic techniques can greatly facilitate the drug research. This review highlights the application of some efficient synthetic techniques in drug research including microwave chemistry, click chemistry, combinatorial chemistry, cascade reactions and multicomponent reactions, as well as the construction of diverse and drug-like compound libraries.
