Research progress of gene recombinant mesenchymal stem cells as tumor targeting delivery vehicles.
- Author:
Tian-Yuan ZHANG
1
;
Yu-Lan HU
;
Wen-Quan LIANG
;
Jian-Qing GAO
Author Information
1. Institute of Phamaceutics, Zhejiang University, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Cell Movement;
genetics;
Drug Carriers;
Gene Targeting;
methods;
Gene Transfer Techniques;
Genetic Therapy;
methods;
Genetic Vectors;
Humans;
Mesenchymal Stromal Cells;
cytology;
metabolism;
physiology;
Neoplasms;
genetics;
therapy;
Recombinant Proteins;
genetics;
metabolism;
Transfection
- From:
Acta Pharmaceutica Sinica
2013;48(8):1209-1220
- CountryChina
- Language:Chinese
-
Abstract:
The applications of targeting gene delivery systems in tumor therapy have attracted extensive attention of researchers in recent years, as they can selectively deliver the therapeutic gene to tumor sites, improve the success rate of gene therapy and reduce the side effects. Therefore, design and development of novel gene delivery vehicles have been a hot area of current research. Recent studies have shown that mesenchymal stem cells (MSCs) have the ability to migrate towards and engraft into the tumor sites. Therefore, these properties make them a great hope for efficient targeted-delivery vehicles in cancer gene therapy. In this review, we examine the promising of utilization of MSCs as a targeted-delivery vehicle for cancer gene therapy, and summarize various challenges and concerns regarding this therapy.
