Halogenated natural products from the marine-derived actinobacteria and their halogenation mechanism.
- Author:
Yi TAN
1
;
Hong-xia ZHOU
1
;
Yi-guang WANG
1
;
Mao-luo GAN
1
;
Zhao-yong YANG
1
Author Information
1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
- Publication Type:Journal Article
- MeSH:
Actinobacteria;
chemistry;
Anti-Bacterial Agents;
chemistry;
isolation & purification;
pharmacology;
Antineoplastic Agents;
chemistry;
isolation & purification;
pharmacology;
Biological Products;
chemistry;
isolation & purification;
pharmacology;
Cell Line, Tumor;
Cell Proliferation;
drug effects;
Halogenation;
Humans;
Marine Biology;
Molecular Structure
- From:
Acta Pharmaceutica Sinica
2013;48(9):1369-1375
- CountryChina
- Language:Chinese
-
Abstract:
In the last decade, along with the development of taxonomy research in marine-derived actinobacteria, more and more halogenated natural products were discovered from marine actinobacteria. Most of them showed good biological activity and unique structure compared to those from land. The special halogenation mechanism in some compounds' biosynthesis has drawn great attention. So in this review, we focus on the halogenated natural products from marine actinobacteria and their halogenation mechanisms.
