Effect of 2-methacryloyloxyethyl phosphorylcholine on the protein-repellent property of dental adhesive.

Ning Zhang; Ke Zhang; Huakun XU; Yuxing Bai

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Effect of 2-methacryloyloxyethyl phosphorylcholine on the protein-repellent property of dental adhesive.

Author: Ning ZHANG ¹ ; Ke ZHANG ¹ ; Huakun XU ² ; Yuxing BAI ¹
Author Information

1. Department of Orthodontics, Capital Medical University School of Stomatology, Beijing 100050, China.
2. Biomaterials & Tissue Engineering Division, University of Maryland Dental School, Baltimore, MD 21201, U S A.
Publication Type:Journal Article
MeSH: Adsorption; Biofilms; drug effects; growth & development; Calcium Phosphates; pharmacology; Dental Cements; pharmacology; Dental Plaque; Dentin; chemistry; Humans; Lactic Acid; biosynthesis; Methacrylates; pharmacology; Nanoparticles; Phosphorylcholine; analogs & derivatives; pharmacology; Resin Cements; pharmacology; Saliva; Tensile Strength
From: Chinese Journal of Stomatology 2016;51(3):172-175
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo evaluate the effect of 2-methacryloyloxyethyl phosphorylcholine (MPC) and nanoparticles of amorphous calcium phosphate (NACP) on the protein-repellent property of dental adhesive.
METHODSMPC and NACP were incorporated into SBMP as the test group. Scotchbond Multi-Purpose (SBMP) was used as control group. Human dentin shear bond strengths were measured. Protein adsorption onto samples was determined by micro bicinchoninic acid (BCA) method. A dental plaque microcosm biofilm model with human saliva as inoculum was used to investigate biofilm viability.
RESULTSThe dentin bond strength of modified group was (28.7±2.2) MPa, which was not significantly different from that of the SBMP control group. The amount of protein adsorption in the modified group and the SBMP control group were (0.21±0.02) µg/cm(2) and (4.17±0.45) µg/cm(2) respectively. Lactic acid production of biofilms in modified group and SBMP control were (7.71 ± 1.01) mmol/L and (19.18 ± 2.34) mmol/L repectively.
CONCLUSIONSMPC-NACP based dental adhesive greatly reduce the protein adsorption and bacterial adhesion, without compromising dentin shear bond strength. This novel bonding agent may have wide application.