Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer.
- Author:
Hai-ping PEI
1
;
Hua GE
;
Rui JIANG
;
Hong ZHU
Author Information
- Publication Type:Journal Article
- MeSH: 14-3-3 Proteins; Adult; Aged; Biomarkers, Tumor; metabolism; Colorectal Neoplasms; metabolism; pathology; Exonucleases; metabolism; Exoribonucleases; Female; HSP27 Heat-Shock Proteins; metabolism; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Proteins; metabolism; Young Adult
- From: Chinese Journal of Gastrointestinal Surgery 2010;13(3):213-215
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of 14-3-3 sigma and heat shock protein 27 (HSP27) in colorectal carcinoma(CRC) tissue and its clinical significance.
METHODSThe expression of 14-3-3 sigma and HSP27 was detected by immunohistochemical staining in 50 pathologically verified CRC cases. The association of clinical data with 14-3-3 sigma and HSP27 expression was examined.
RESULTSThe positive expression rate of 14-3-3 sigma was 10% in normal control mucosa and 58% in CRC tissue (P<0.01). The positive expression rate of HSP27 was 16% in normal control mucosa and 54% in CRC tissue (P<0.01). No correlation between 14-3-3 sigma and HSP27 expression was found in CRC tissue (P>0.05). The expression of 14-3-3 sigma was associated with patient age, tumor diameter and lymph node metastasis (LNM) (P<0.05), but not with gender, tumor differentiation or serous membrane invasion (P>0.05). The expression of HSP27 was associated with LNM (P<0.05), but not with gender, age, differentiation, tumor diameter or serous membrane invasion (P>0.05).
CONCLUSIONThe abnormal expression of 14-3-3 sigma and HSP27 is significantly associated with LNM in CRC.
