Transforming growth factor-beta and its receptors in scleroderma.
- Author:
Huan QIAN
1
;
Min ZHENG
Author Information
1. Department of Dermatology and Venereology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Extracellular Matrix;
metabolism;
pathology;
Extracellular Matrix Proteins;
metabolism;
Fibroblasts;
metabolism;
Fibrosis;
Humans;
Receptors, Transforming Growth Factor beta;
metabolism;
Scleroderma, Systemic;
etiology;
metabolism;
Transforming Growth Factor beta;
metabolism
- From:
Journal of Zhejiang University. Medical sciences
2009;38(4):415-421
- CountryChina
- Language:Chinese
-
Abstract:
The hallmark of scleroderma is fibrosis by excessive extracellular matrix (ECM) deposition in the skin, lung, and other organs. Increasing evidence suggests that overexpression of transforming growth factor-beta (TGF-beta) and its receptors play a key pathogenic role in the development of tissue fibrosis in scleroderma. TGF-beta is known to induce the expression of ECM proteins in the pathogenesis of fibrosis in systemic sclerosis. Investigations into TGF-beta pathways will suggest new treatment strategies for fibrotic diseases.
