Advances of research on vascular endothelial growth factor receptors in epidermal neoplasm.
- Author:
Ping YANG
1
;
Min ZHENG
Author Information
1. Department of Dermatology and Venereology, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Epidermis;
metabolism;
Humans;
Neoplasms;
metabolism;
Neuropilins;
genetics;
metabolism;
Receptors, Vascular Endothelial Growth Factor;
genetics;
metabolism;
Vascular Endothelial Growth Factor Receptor-1;
genetics;
metabolism;
Vascular Endothelial Growth Factor Receptor-2;
genetics;
metabolism;
Vascular Endothelial Growth Factor Receptor-3;
genetics;
metabolism
- From:
Journal of Zhejiang University. Medical sciences
2009;38(4):422-426
- CountryChina
- Language:Chinese
-
Abstract:
Vascular endothelial growth factor (VEGF) exerts its biological functions by its specific VEGF receptors (VEGFRs), which includes VEGFR-1, VEGFR-2, VEGFR-3, neuropilin-1 and neuropilin-2. These VEGF receptors not only distribute in endothelial cells, but also in epidermal keratinocytes. VEGFRs may play a significant role in pathogenesis of the epidermal neoplasm and the VEGF-VEGFR signaling pathway may be a novel therapy target for neoplasm derived from epidermis.
