Adjunctive Low-frequency Repetitive Transcranial Magnetic Stimulation over the Right Dorsolateral Prefrontal Cortex in Patients with Treatment-resistant Obsessive-compulsive Disorder: A Randomized Controlled Trial.
10.9758/cpn.2016.14.2.153
- Author:
Ho Jun SEO
1
;
Young Eun JUNG
;
Hyun Kook LIM
;
Yoo Hyun UM
;
Chang Uk LEE
;
Jeong Ho CHAE
Author Information
1. Departments of Psychiatry, St. Vincent Hospital, Suwon, Korea.
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Transcranial magnetic stimulation;
Obsessive-compulsive disorder;
Prefrontal cortex
- MeSH:
Anxiety;
Depression;
Humans;
Obsessive-Compulsive Disorder*;
Prefrontal Cortex*;
Sample Size;
Transcranial Magnetic Stimulation*
- From:Clinical Psychopharmacology and Neuroscience
2016;14(2):153-160
- CountryRepublic of Korea
- Language:English
-
Abstract:
OBJECTIVE: The present study aimed to evaluate the efficacy of low frequency (LF) repetitive transcranial magnetic stimulation (rTMS) over the right dorsolateral prefrontal cortex (DLPFC) for the treatment of obsessive-compulsive disorder (OCD). METHODS: Twenty-seven patients with treatment resistant OCD were randomly assigned to 3 week either active (n=14) or sham (n=13) rTMS. The active rTMS parameters consisted of 1 Hz, 20-minute trains (1,200 pulses/day) at 100% of the resting motor threshold (MT). OCD symptoms, mood, and anxiety were assessed at baseline and every week throughout the treatment period. RESULTS: A repeated-measures analysis of variance (ANOVA) was used to evaluate changes on the Yale-Brown Obsessive Compulsive Scale (YBOCS). Our results revealed a significant reduction in YBOCS scores in the active group compared with the sham group after 3 weeks. Similarly, a repeated-measures ANOVA revealed significant effect of time and time×group interaction on scores on the Hamilton Depression Rating Scale and the Clinical Global Impression-Severity scale. There were no reports of any serious adverse effects following the active and sham rTMS treatments. CONCLUSION: LF rTMS over the right DLPFC appeared to be superior to sham rTMS for relieving OCD symptoms and depression in patients with treatment-resistant OCD. Further trials with larger sample sizes should be conducted to confirm the present findings.
