Relationship of polymorphism of SG13S114A/T in ALOX5AP gene with atherosclerotic cerebral infarction.
- Author:
Ying-Lei HE
1
;
Min ZHU
;
Xiao-Ping JIN
;
Yuan-Lin ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: 5-Lipoxygenase-Activating Proteins; genetics; Alleles; Cerebral Infarction; etiology; genetics; Female; Genotype; Humans; Intracranial Arteriosclerosis; complications; genetics; Male; Polymorphism, Restriction Fragment Length
- From: Journal of Zhejiang University. Medical sciences 2009;38(6):630-633
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship of the polymorphism of SG13S114A/T in ALOX5AP gene with atherosclerotic cerebral infarction (ACI).
METHODSBy polymerase chain reaction and restriction fragment length polymorphism, polymorphism of SG13S114A/T in ALOX5AP gene in 412 cases with ACI and 368 non-ACI controls were analyzed.
RESULTThere were no statistically significant differences in the ALOX5AP gene SG13S114 AA genotype and A allele frequencies between ACI group and control group (P>0.05).
CONCLUSIONThe results do not support genotype SG13S114 A allele as the risk gene for ACI.control group.
