PICK1 is associated with central nervous system diseases.
- Author:
Yu-Ting LU
1
;
Li-Jun ZHU
Author Information
1. Institute of Neuroscience, College of Medicine, Zhejiang University, Hangzhou 310058, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Carrier Proteins;
chemistry;
metabolism;
physiology;
Epilepsy;
metabolism;
Humans;
Nuclear Proteins;
chemistry;
metabolism;
physiology;
Schizophrenia;
metabolism;
Stroke;
metabolism
- From:
Journal of Zhejiang University. Medical sciences
2009;38(6):649-654
- CountryChina
- Language:Chinese
-
Abstract:
PICK1 (protein interacting with C kinase 1) contains a PDZ (PSD-95/Dlg/ZO1) domain and a BAR (Bin/amphiphysin/Rvs) domain. Via the PDZ domain, PICK1 interacts directly with more than 40 proteins. Among these interacting proteins, some are important for physiological and pathophysiological processes of central nervous system. In this review, recent findings about how PICK1 is associated with central nervous system diseases are summarize.
