Traditional Chinese medicine Drynaria fortunei J. Smith naringin promotes proliferation and differentiation of human periodontal ligament cells.
- Author:
Qi-yong HU
1
;
Li-li CHEN
;
Ren-fei WANG
Author Information
- Publication Type:Journal Article
- MeSH: Cell Differentiation; drug effects; Cell Proliferation; drug effects; Cells, Cultured; Drugs, Chinese Herbal; pharmacology; Flavanones; isolation & purification; pharmacology; Humans; Osteoblasts; cytology; Periodontal Ligament; cytology; Polypodiaceae; chemistry
- From: Journal of Zhejiang University. Medical sciences 2010;39(1):79-83
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effects of Drynaria fortunei J. Smith naringin (DFSN) on proliferation and differentiation of human periodontal ligament cells (hPDLC).
METHODSCultured human periodontal ligament cells were treated with DFSN at different concentrations. Cell proliferation was determined by MTT method; cell differentiation was evaluated through the examination of alkaline phosphate (ALP) activities.
RESULTSDFSN in a concentration ranged from 0.01 mu mol/L to 10 mu mol/L showed a promoting effect on proliferation of hPDLC (P< 0.05), and it also promoted ALP activities of hPDLC (P<0.05).
CONCLUSIONDrynaria fortunei J. Smith naringin can promotes the proliferation and differentiation of human periodontal ligament cells.
