Magnetic resonance signal features of superparamagnetic iron oxide with different particle size and concentration.
- Author:
Bing-ying LIN
1
;
Jing-feng ZHANG
;
Min-ming ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Contrast Media; pharmacology; Dose-Response Relationship, Drug; Ferrosoferric Oxide; chemistry; pharmacology; Humans; Image Enhancement; Magnetic Resonance Imaging; methods; Magnetite Nanoparticles; chemistry; Particle Size
- From: Journal of Zhejiang University. Medical sciences 2010;39(2):125-129
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the magnetic resonance (MR) signal features of superparamagnetic iron oxide (SPIO) with different particle size and concentration.
METHODSThe superparamagnetic iron oxide with different concentration and particle size was scanned by magnetic resonance; T1, T2 and T2(*) values of each group were recorded to evaluate the features of MR signals.
RESULTSThe T1 value of SPIO with different particle size had negative linear relationship with concentration. In low concentration the T2 and T2(*) values were elevated markedly with the particle size decreased; while in high concentration the T2 and T2(*)values were elevated gently with particle size decreased. lg(T2), particle size and concentration of SPIO had linear relationship.
CONCLUSIONSSPIO affects magnetic resonance signal mainly with effect on T1 and T2. T2 value can be regarded as the major detection index in the magnetic resonance scan of SPIO. There is a linear relationship among particle size, SPIO concentration and lg(T2) value.
