Evaluation of biochemical metabolites by 31P MR spectroscopy in leukemic infiltration of liver.
- Author:
Jian-zhong SUN
1
;
Zhi-kang WANG
;
Ri-sheng YU
;
Lian-sheng HUANG
;
Xiu-fang XU
;
Min-ming ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Adult; Aged; Female; Humans; Leukemia; pathology; Leukemic Infiltration; metabolism; pathology; Liver; metabolism; pathology; Magnetic Resonance Spectroscopy; methods; Male; Middle Aged; Phosphorus Isotopes; metabolism; Young Adult
- From: Journal of Zhejiang University. Medical sciences 2010;39(2):150-156
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the changes of phosphorus metabolites in leukemic infiltration of liver (LIL) with two-dimensional chemical shift imaging(2D CSI)(31)phosphorus MR spectroscopy ((31)P MRS).
METHODSFifteen patients with LIL and 12 healthy subjects (control group) were scanned with liver 2D CSI(31)P MRS by a 1.5T MR Scanner(Sonata, Siemens Corporation). Relative quantification of phosphorus metabolites including phosphomonoesters (PME), inorganic phosphate (Pi), phosphodiesters (PDE) and beta-adenosine- triphosphate (beta-ATP) were detected and after calibrated with model factor, the ratios of PME/PDE, PME/(PME+PDE), PME/ATP, PDE/ATP and Pi/ATP were analyzed.
RESULTSCompared with control group, the PME value, PME/PDE ratio, PME/(PME+PDE) ratio and PME/ATP ratio were increased in LIL group (1.992 +/-0.876 Compared with 1.167 +/-0.427, P <0.05), (0.551 +/-0.339 Compared with 0.254 +/-0.059,P <0.01), (0.326 +/-0.13 Compared with 0.199 +/-0.049, P <0.01)and (1.402 +/-0.654 Compared with 0.792 +/-0.232, P <0.01) respectively.
CONCLUSION(31)P MRS examination can be used as a non-invasive procedure to evaluate the changes of phosphorus metabolites of leukemic infiltration of liver. The increase of PME value and its ratios to PDE, ATP and PME+PDE may indicate leukemic infiltration of liver.
