Value of diffusion-weighted MR imaging in diagnosis of acute rejection after renal transplantation.
- Author:
Jing-jing XU
1
;
Wen-bo XIAO
;
Lei ZHANG
;
Min-ming ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Diffusion Magnetic Resonance Imaging; Female; Graft Rejection; diagnosis; Humans; Kidney; physiopathology; Kidney Transplantation; adverse effects; Male; Sensitivity and Specificity
- From: Journal of Zhejiang University. Medical sciences 2010;39(2):163-167
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the feasibility of MR diffusion-weighted imaging (DWI) in diagnosis of acute rejection after renal transplantation.
METHODSSixty-nine patients who underwent renal transplantation were enrolled in the study. According to the clinical features and renal biopsy, 26 patients were designated in rejection group and 43 in non-rejection group. Patients in non-rejection group underwent MR DWI scan at 2 to 3 weeks after operation, and those in rejection group underwent scan at 5 d before or after renal biopsy. Then the apparent diffusion coefficient (ADC) values of transplanted kidneys were measured with high diffusion sensitivity gradient factors (b values).
RESULTSPatients with acute rejection had significantly lower ADC (P <0.04) than non-rejection patients with all the different b values (b=200, 400, 600, 800, 1,000 s/mm(2)). The ROC curves showed that sensitivity and specificity were best when b value was 800 s/mm(2).
CONCLUSIONDWI is a potential and reliable non-invasive method for the diagnosis of the acute rejection after renal transplantation.
