Value of 18F-FDG-PET/CT in diagnosis of classic fever of unknown origin.
- Author:
Kui ZHAO
1
;
Meng-jie DONG
;
Ling-xiang RUAN
;
Zhen-feng LIU
;
Shu-ye YANG
;
Guo-lin WANG
;
Fang SUN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Diagnosis, Differential; Female; Fever of Unknown Origin; diagnosis; diagnostic imaging; etiology; Fluorodeoxyglucose F18; Humans; Male; Middle Aged; Positron-Emission Tomography; methods; Radiopharmaceuticals; Tomography, X-Ray Computed; methods; Young Adult
- From: Journal of Zhejiang University. Medical sciences 2010;39(2):174-180
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the application of (18)F-FDG PET/CT in diagnosis of classic fever of unknown origin.
METHODSA total of 27 consecutive patients with classic fever of unknown origin (FUO) (19 men, 8 women; aged 24-82 y) underwent (18)F-FDG PET/CT scans. The images were interpreted by visual inspection and semiquantitative analysis(standardized uptake value, SUV). Final diagnosis was based on histopathology or clinical follow-up.
RESULTSThe cause of FUO was confirmed by followed investigations in 21 of 27 cases after PET/CT scan, including 10 cases of infection, 4 of noninfectious inflammation, 4 of malignancies and 3 of miscellaneous disorders; and remaining 6 cases were still confirmed FUO. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy were 100.0 %, 83.3%, 83.3%, 100.0% and 96.3%, respectively.
CONCLUSIONFor patients with fever of unknown origin, (18)F-FDG-PET/CT can be a sensitive, reliable imaging modality. It is suggested that (18)F-FDG-PET/CT should be considered earlier in detecting the causes of FUO, which is difficultly diagnosed by conventional modalities.
