Clinical analysis of 24 cases of acute myeloid leukemia with 3q abnormalities.
- Author:
Ying LU
1
;
Zhi-mei CHEN
;
Wei-lai XU
;
Qi-tian MU
;
Jie JIN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Chromosome Aberrations; Chromosome Banding; Chromosomes, Human, Pair 3; genetics; Female; Humans; Karyotyping; Leukemia, Myeloid, Acute; genetics; Male; Middle Aged; Prognosis; Retrospective Studies; Young Adult
- From: Journal of Zhejiang University. Medical sciences 2010;39(3):241-245
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the clinical characteristics of acute myeloid leukemia patients with 3q abnormalities.
METHODSConventional cytogenetic analysis of R-banding was used to detect the abnormalities of 3q in 657 patients with acute myeloid leukemia (AML).
RESULTTwenty-four (3.7%) out of 657 patients had abnormalities of 3q, of which 3q21 or 3q26 were involved in 18 cases (75.0%); 3q21q26 abnormalities were harbored in 11 patients (45.8%), including 9 of t (3;3) and 2 cases of inv (3), of which 3 cases progressed from MDS. Ten patients presented with normal or elevated platelets and their bone marrow morphologies showed abnormal and striking proliferation of megakaryocytes. While in other 7 patients with 3q21 or 3q26, no one presented with high platelets and megakaryocytes. All 24 patients with 3q abnormalities received chemotherapies and only 4 patients achieved short-term remission with a median survival time of 6.7 months.
CONCLUSION3q21q26 anomaly is the most common karyotype in acute myeloid patients with 3q abnormalities. The patients with 3q anomaly had extremely poorer treatment outcome and prognosis.
