Research progress on autophagy in hematopoietic malignancies.
- Author:
Yin TONG
1
;
Lu LI
;
Hui LIU
;
Wen-bin QIAN
Author Information
1. The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
physiology;
Autophagy;
physiology;
Cell Death;
physiology;
Hematologic Neoplasms;
pathology;
physiopathology;
Signal Transduction
- From:
Journal of Zhejiang University. Medical sciences
2010;39(3):246-249
- CountryChina
- Language:Chinese
-
Abstract:
Autophagy is a process of bulk degradation of proteins and organelles in cytoplasm.Autophagy has many normal physiological functions in cellular catabolism; therefore is essential for cell homeostasis. In some circumstances autophagy can induces cell death, namely autophagic cell death. Recent studies have suggested that autophagy plays an important role in both normal tissue development and a variety of diseases, including cancer. Therefore, the strategy targeting autophagy pathway may represent a new way of cancer treatment.
