Advances in apolipoprotein A- I and it's anti-atherosclerosis properties.
- Author:
Ming LI
1
;
Zhi-Min LIU
Author Information
1. Institute of Biotechnology, Academy of Military Medical Sciences, Beijing 100071, China. liming096@sina.com
- Publication Type:Journal Article
- MeSH:
Animals;
Apolipoprotein A-I;
chemistry;
metabolism;
physiology;
Atherosclerosis;
metabolism;
prevention & control;
Cholesterol;
metabolism;
Humans;
Lipoproteins, HDL;
metabolism;
physiology
- From:
Chinese Journal of Biotechnology
2003;19(4):387-391
- CountryChina
- Language:Chinese
-
Abstract:
Human apolipoprotein A- I, the major protein component of high density lipoproteins and the main activator of the enzyme lecithin: cholesterol acyltransferase, defines the structure and stability and functions of HDL. It is clearly demonstrated that high concentration of the apoA- I not only inhibits the initiation and progression of atherosclerosis, but also makes the preexisting atherosclerotic lesions regress. This review gives an overview of the apoA- I structure, production, relation between apoA- I and HDL, and several mechanisms of the apoA-I anti-atherosclerosis. These mechanisms include directing excess celluar cholesterol from the peripheral tissues to the liver in reverse cholesterol transport, inhibiting oxidative modification of LDL, and modulating inflammatory responses to favour vasoprotection.
