Application of element and metabolism balancing for the cultivation process with Streptomyces aureofaciens.
- Author:
Jiao-Long FU
1
;
Ying-Ping ZHUANG
;
Ming-Zhi HUANG
;
Ju CHU
;
Si-Liang ZHANG
Author Information
1. State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China.
- Publication Type:Journal Article
- MeSH:
Chlortetracycline;
metabolism;
Fermentation;
physiology;
Models, Theoretical;
Streptomyces aureofaciens;
growth & development;
metabolism
- From:
Chinese Journal of Biotechnology
2003;19(4):471-475
- CountryChina
- Language:Chinese
-
Abstract:
On the base of element and metablism balancing, the mathematical model of the cultivation process with Streptomyces aureofaciens was developed, and the unknown parameters in the model were estimated with the method of nonlinear optimization. Firstly the energetic coefficient of CTC biosynthesis was gained, which was 1.8 - 2.8 mol-ATP x C-mol(-1). The macroscopic reaction rates were predicted in the process and compared with the experimental values. The results show that the model can preferably describe the relationships between several macroscopic reaction rates in the process and can supervise the optimization of CTC fermentation process theoretically.
