Expressions of CD1a and CD83 of Langerhans cells in the local lesions of epidermodysplasia verruciformis patients.
- Author:
Si LIANG
1
;
Yue-Hua LIU
;
Ya-Gang ZUO
;
Bao-Xi WANG
;
Kai FANG
Author Information
- Publication Type:Journal Article
- MeSH: Antigens, CD; biosynthesis; genetics; Antigens, CD1; biosynthesis; genetics; Epidermodysplasia Verruciformis; immunology; pathology; Humans; Langerhans Cells; immunology; Leukocyte Immunoglobulin-like Receptor B1; Receptors, Immunologic; biosynthesis; genetics; Skin; immunology; pathology
- From: Acta Academiae Medicinae Sinicae 2009;31(1):17-19
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expressions of CD1a and CD83 of Langerhans cells (LC) in the lesions of epidermodysplasia verruciformis (EV) patients.
METHODSWe used immunohistochemical method to detect the expressions of CD1a and CD83 in the lesions of 10 patients with EV lesions and in the skins of 10 normal subjects.
RESULTSNo CD83 + LCs was detected in all EV patients and normal controls, but CD1a + LC was found in all cases. The quantity of CD1a + LCs in the lesions of EV patients was significantly lower than that in the normal skin (P < 0.01); furthermore, the distribution of LCs in EV lesions was uneven.
CONCLUSIONThe functions of LCs may be inhibited in EV patients.
