In vivo proton magnetic resonance spectroscopy of hepatocellular carcinoma and cholangiocarcinoma.
- Author:
Ai-Sheng DONG
1
;
Jian-Ming TIAN
;
Jian-Ping LU
;
Chang-Jing ZUO
;
Li WANG
;
Jian WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Bile Duct Neoplasms; diagnosis; metabolism; Bile Ducts, Intrahepatic; metabolism; pathology; Carcinoma, Hepatocellular; diagnosis; metabolism; Case-Control Studies; Cholangiocarcinoma; diagnosis; metabolism; Female; Humans; Liver Neoplasms; diagnosis; metabolism; Magnetic Resonance Imaging; methods; Magnetic Resonance Spectroscopy; methods; Male; Middle Aged; Protons; Retrospective Studies
- From: Acta Academiae Medicinae Sinicae 2009;31(2):151-154
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the value of in vivo proton magnetic resonance spectroscopy (1H MRS) in the assessment of hepatocellular carcinoma (HCC) and cholangiocarcinoma.
METHODS1H MRS was performed in normal volunteers and in patients with pathologically confirmed HCC and cholangiocarcinomas using a whole-body 1.5-T scanner. The choline-to-lipid ratios were measured by dividing the peak area of choline at 3.2 ppm and lipid at 1.3 ppm.
RESULTSThe ratio of choline-to-lipid for normal liver, cholangiocarcinomas, and HCC were 0.07 +/- 0.04, 0.11 +/- 0.06, and 0.52 +/- 0.15, respectively. The ratio of choline-to-lipid was significantly higher in HCC compared than those in cholangiocarcinomas or normal livers (P < 0.05). However, it was not significantly different between cholangiocarcinomas and normal livers (P > 0.05).
CONCLUSIONIn vivo 1H MRS can reflect the pathological changes of HCC and cholangiocarcinomas at metabolic level and thus is useful in the diagnosis of these two cancers.
