Application of 1H-magnetic resonance spectroscopy in differential diagnosis of brain low-grade gliomas and demyelinating diseases.
- Author:
Xin-Yi HOU
1
;
Pei-Yi GAO
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Brain Neoplasms; diagnosis; metabolism; Child; Demyelinating Diseases; diagnosis; metabolism; Diagnosis, Differential; Female; Glioma; diagnosis; metabolism; Humans; Magnetic Resonance Imaging; methods; Magnetic Resonance Spectroscopy; methods; Male; Middle Aged; Young Adult
- From: Acta Academiae Medicinae Sinicae 2009;31(2):206-209
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinical value of 1H-magnetic resonance spectroscopy (1H-MRS) in differential diagnosis of brain low-grade gliomas and demyelinating diseases.
METHODS1H-MRS was performed in 24 patients with low-grade gliomas and 22 patients with demyelinating diseases and the results were retrospectively reviewed. The metabolites including N-acetyl aspartate (NAA), choline (Cho), and creatine (Cr) were detected in different areas including lesions and the normal brain. The ratios of NAA/Cr, NAA/Cho, and Cho/Cr were also computed.
RESULTSCompared with the normal brain tissue, low-grade gliomas and demyelinating diseases had significantly different ratios of NAA/Cr, NAA/Cho, and Cho/Cr (P < 0.05). The ratios of NAA/Cho and Cho/Cr were significantly different between low-grade gliomas and demyelinating diseases (P < 0.05), while the ratio of NAA/Cr was not significantly different (P > 0.05).
CONCLUSIONSThe ratio of NAA/Cho and Cho/Cr is remarkably different between low-grade gliomas and demyelinating diseases. It can a useful indicator for differential diagnosis of these two diseases by 1H-MRS.
