Minimization or avoidance of calcineurin inhibitors after renal transplantation.
- Author:
Chong XUE
1
;
Zhi-gang JI
Author Information
1. Department of Urology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
- Publication Type:Journal Article
- MeSH:
Calcineurin Inhibitors;
Graft Rejection;
prevention & control;
Humans;
Immunosuppressive Agents;
administration & dosage;
adverse effects;
Kidney Transplantation
- From:
Acta Academiae Medicinae Sinicae
2009;31(3):280-283
- CountryChina
- Language:Chinese
-
Abstract:
Calcineurin inhibitors (CNIs) are playing an important role in preventing acute rejection in renal transplantation; however, their nephrotoxicity may impact long-term renal allograft survival. Several CNI-sparing regimens (such as CNI-avoidance or CNI-minimization) have shown at least comparable efficacy with standard-dose CNI regimens. Research continues to achieve the "best" balance between efficacy and toxicity of available immunosuppressive regimens.
