Pathogenesis of post-transplantation diabetes mellitus in 40 renal transplantation recipients.
- Author:
Zhen WANG
1
;
Bing-yi SHI
;
Hui-li ZHENG
;
Ye-yong QIAN
;
Meng-xia HAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Diabetes Mellitus; etiology; physiopathology; Female; Humans; Insulin Resistance; Insulin-Secreting Cells; physiology; Kidney Transplantation; Male; Middle Aged; Postoperative Complications; etiology; physiopathology; Retrospective Studies; Young Adult
- From: Acta Academiae Medicinae Sinicae 2009;31(3):292-295
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore pathogenesis of post-transplantation diabetes mellitus (PTDM) in renal transplantation recipients.
METHODSA total of 40 renal transplantation recipients were divided into three groups based on oral glucose tolerance test results: normal glucose tolerance (NGT) group (n = 10), impaired fasting glycaemia + impaired glucose tolerance (IFG + IGT) group (n = 16), and PTDM group (n = 14). Insulin resistance (IR) and beta cell function were assessed by homeostasis model.
RESULTSThe differences of the immunosuppressive agents used in these groups were not statistically significant (P > 0.05). Compared with NGT group, insulin area under curve and homeostasis model assessment-insulin resistance index were significantly higher in IGT + IFG group and PTDM group (P < 0.05). Compared with NGT group and IGT + IPG group, insulin secretion index at 30 min and homeostasis model assessment-insulin secretion index were significantly lower in PTDM group (P < 0.05).
CONCLUSIONInsulin resistance and beta-cell dysfunction may play a key role in the pathogenesis of PTDM.
