Effect of low-flux polysulphone membranes on the serum levels of inflammatory cytokines, C-reactive protein, lipoprotein (a), and beta2 microglobulin in hemodialysis patients.
- Author:
Jian-Ling TAO
1
;
Yang SUN
;
Xue-Mei LI
;
Hang LI
;
Yu-Ying WANG
;
Xue-Wang LI
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; C-Reactive Protein; metabolism; Female; Humans; Interleukin-1beta; blood; Interleukin-6; blood; Lipoprotein(a); blood; Male; Membranes, Artificial; Middle Aged; Polymers; Renal Dialysis; Sulfones; beta 2-Microglobulin; blood
- From: Acta Academiae Medicinae Sinicae 2009;31(3):362-364
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the effect of low-flux polysulphone membranes on the serum levels of inflammatory cytokines, hyper-sensitivity C reactive protein (hsCRP), lipoprotein (a) [Lp (a)], and beta2 microglobulin (beta 2MG) in hemodialysis patients.
METHODSThe blood samples and dialysate samples were collected at pre-dialysis, 120 minutes later during the session, and post-dialysis in 27 stable hemodialysis patients. Variables determined included serum Lp (a), hsCRP, interleukin (IL)-1 beta, IL-6, and beta 2MG. The endotoxin levels were also detected.
RESULTSThere were no significant changes either in endotoxin level of dialysate or in all variables tested during one session (P > 0.05).
CONCLUSIONLow-flux polysulphone membrane has no effects on serum Lp (a), hsCRP, IL-1 beta, IL-6, and beta 2MG during one session in hemodialysis patients.
