Dynamic Changes in DNA Damage and Repair Biomarkers with Employment Length among Nickel Smelting Workers.
- Author:
Shan WU
1
,
2
;
Ya Na BAI
1
;
Hong Quan PU
3
;
Jie HE
4
;
Tong Zhang ZHENG
5
;
Hai Yan LI
3
;
Min DAI
4
;
Ning CHENG
6
Author Information
- Publication Type:Letter
- MeSH: Biomarkers; Case-Control Studies; Cohort Studies; DNA Damage; drug effects; DNA Glycosylases; blood; DNA Repair; Deoxyadenosines; blood; Humans; Male; Metallurgy; Nickel; toxicity; urine; Occupational Exposure; adverse effects; Time Factors
- From: Biomedical and Environmental Sciences 2015;28(9):679-682
- CountryChina
- Language:English
- Abstract: Our study explored the dynamic changes in and the relationship between the DNA damage marker 8-hydroxy-2'-deoxyguanosine (8-OHdG) and the DNA repair marker 8-hydroxyguanine DNA glycosidase 1 (hOGG1) according to the length of occupational employment in nickel smelting workers. One hundred forty nickel-exposed smelting workers and 140 age-matched unexposed office workers were selected from the Jinchang cohort. The 8-OHdG levels in smelting workers was significantly higher than in office workers (Z=-8.688, P<0.05) and the 8-OHdG levels among nickel smelting workers in the 10-14 y employment length category was significantly higher than among all peers. The hOGG1 levels among smelting workers were significantly lower than those of non-exposed workers (Z=-8.948, P<0.05). There were significant differences between employment length and hOGG1 levels, with subjects employed in nickel smelting for 10-14 y showing the highest levels of hOGG1. Correlation analysis showed positive correlations between 8-OHdG and hOGG1 levels (r=0.413; P<0.01). DNA damage was increased with employment length among nickel smelting workers and was related to the inhibition of hOGG1 repair capacity.
