Assessing Adverse Effects of Aroclor 1254 on Perinatally Exposed Rat Offspring.

Wei Tang; Jin Ping Cheng; Yi Chen Yang; Wen Hua Wang

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Assessing Adverse Effects of Aroclor 1254 on Perinatally Exposed Rat Offspring.

Author: Wei TANG ¹ ; Jin Ping CHENG ¹ ; Yi Chen YANG ¹ ; Wen Hua WANG ¹
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1. School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China.
Publication Type:Letter
MeSH: Aging; metabolism; Animals; Cerebral Cortex; drug effects; enzymology; metabolism; Chlorodiphenyl (54% Chlorine); toxicity; Female; Glutathione Peroxidase; metabolism; Kidney; drug effects; enzymology; metabolism; Lipid Peroxidation; drug effects; Liver; drug effects; enzymology; metabolism; Mice; Nervous System; drug effects; growth & development; metabolism; physiopathology; Nervous System Diseases; chemically induced; Nitric Oxide; metabolism; Nitric Oxide Synthase; metabolism; Oxidative Stress; drug effects; Pregnancy; Prenatal Exposure Delayed Effects; chemically induced; Random Allocation; Rats; Superoxide Dismutase; metabolism
From: Biomedical and Environmental Sciences 2015;28(9):687-690
CountryChina
Language:English
Abstract: To assess the neurotoxic effects and redox responses of Aroclor 1254 (A1254) on perinatally exposed rat offspring, A1254 was administered by gavage from gestational day (GD) 6 to postnatal day (PND) 21. Neurobehavioral development, antioxidant enzyme activities, lipid peroxidation (LPO), nitric oxide (NO), and NO synthase (NOS) levels were analyzed in the offspring. Neurobehavioral development analysis revealed delayed appearance of the righting reflex, negative geotaxis, and cliff drop test responses in A1254 exposed group. Developmental A1254 exposure also caused oxidative stress in the brain of PND 22 offspring via reductions in the activity of SOD and GSH-Px, and by promoting a rise in the levels of NO and NOS.