Protective Effects of Tetramethylpyrazine on Cerebrovascular Regulations in Rats with Chronic Alcoholic Encephalopathy.
- Author:
Hui LI
1
;
Xue YANG
2
;
Wei SHI
3
;
Zhao MA
4
;
Guang Kun FENG
1
;
Yan Ling YIN
1
;
Yan Xia FAN
1
;
Jie JIANG
4
Author Information
- Publication Type:Letter
- MeSH: Alcohol-Induced Disorders, Nervous System; complications; drug therapy; physiopathology; Animals; Cerebrovascular Circulation; drug effects; Disease Models, Animal; Endothelin-1; blood; Learning; drug effects; Male; Memory; drug effects; Pyrazines; pharmacology; therapeutic use; Random Allocation; Rats; Rats, Wistar; Vascular Endothelial Growth Factor A; analysis; Vasodilator Agents; pharmacology; therapeutic use
- From: Biomedical and Environmental Sciences 2015;28(9):691-695
- CountryChina
- Language:English
- Abstract: Recent studies showed that pathology of alcoholic encephalopathy was associated with cerebral vascular damage. TMP (tetramethyl- pyrazine) is widely used in the treatment of cerebrovascular diseases, however, it has not been reported whether TMP can relieve alcohol-induced cerebral vascular damages. The study was performed to investigate the learning and memory, cerebrovascular pathological changes and the expressions of vascular endothelial growth factor (VEGF) and serum levelsofendothelin-1 (ET-1) in the rat model of chronic alcoholic encephalopathy, and explore the effects of TMP intervention on alcoholic encephalopathy. In the present study, the rat model of chronic alcoholic encephalopathy was established by the gavage administration of alcohol; the learning and memory ability was tested by Morris water maze; the expression of VEGF was measured by RT-PCR and Western blot; and the serum levels of ET-1 was measured by radioimmunoassay. We found that alcohol intoxication impaired learning and memory, induced VEGF overexpression and increased ET 1 concentrations. TMP intervention improved learning abilities, increased the VEGF expression and reduced ET-1 level. These results indicate that TMP exhibits therapeutic effects on chronic alcoholic encephalopathy.
