Association Between Serum Uric Acid and Prevalence of Type 2 Diabetes Diagnosed using HbA1c Criteria Among Chinese Adults in Qingdao, China.

Bai Xue; Ji Bin Tan; Feng Ning; Jian Ping Sun; Ke Yi Zhang; Li Liu; Shao Jie Wang; Dong Feng Zhang; Qing Qiao; Zeng Chang Pang

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Association Between Serum Uric Acid and Prevalence of Type 2 Diabetes Diagnosed using HbA1c Criteria Among Chinese Adults in Qingdao, China.

Author: Bai XUE ^{1
,

2} ; Ji Bin TAN ³ ; Feng NING ⁴ ; Jian Ping SUN ⁴ ; Ke Yi ZHANG ⁴ ; Li LIU ⁴ ; Shao Jie WANG ⁴ ; Dong Feng ZHANG ⁵ ; Qing QIAO ⁶ ; Zeng Chang PANG ⁴
Author Information

1. Department of Nutrition and Food Hygiene, Medical College of Qingdao University, Qingdao 260071, Shandong, China
2. Center for Disease Control and Prevention, Qingdao 266033, Shandong, China.
3. School of Public Health, Jilin University, Changchun 130021, Jilin, China
4. Center for Disease Control and Prevention, Qingdao 266033, Shandong, China.
5. Department of Nutrition and Food Hygiene, Medical College of Qingdao University, Qingdao 260071, Shandong, China.
6. Department of Public Health, University of Helsinki 00014, Finland.
Publication Type:Journal Article
Keywords: Cardiometabolic parameters; Hemoglobin A1c; Type 2 diabetes; Uric acid
MeSH: Adult; Aged; Asian Continental Ancestry Group; statistics & numerical data; China; epidemiology; Cross-Sectional Studies; Diabetes Mellitus, Type 2; blood; epidemiology; Female; Glycated Hemoglobin A; metabolism; Humans; Male; Middle Aged; Prevalence; Uric Acid; blood
From: Biomedical and Environmental Sciences 2015;28(12):884-893
CountryChina
Language:English
Abstract:
OBJECTIVETo determine whether elevated serum uric acid (UA) levels are associated with type 2 diabetes diagnosed using HbA1c levels among Chinese adults.
METHODSWe conducted two population-based cross-sectional studies in Qingdao in China in 2006 and 2009. A total of 6894 (39.4% men) subjects aged 35-74 years were included in the data analysis. Newly diagnosed diabetes was defined as HbA1c level of ⋝6.5%, and prediabetes was classified as HbA1c level between 5.7% and 6.4% according to the International Diabetes Federation criteria. Multivariate logistic regression was employed to assess the association between UA and prevalence of type 2 diabetes defined using Glycated hemoglobin A1c (HbA1c) levels.
RESULTSSubjects with prediabetes had higher UA levels than those with normal glucose tolerance, newly diagnosed diabetes, and known diabetes, with corresponding values of 325.1 (82.5) µmol/L, 310.9 (84.2) µmol/L, 291.3 (81.7) µmol/L, 305.2 (83.6) µmol/L, respectively (P<0.001 for all comparisons). Binary logistic regression analysis showed that UA was a possible predictor for the prevalence of type 2 diabetes diagnosed using HbA1c levels, and the second quartile of UA levels had a higher odds ratio (OR: 4.088; 95% CI: 2.900-5.765) for HbA1c than the other quartiles after adjusting for age, body mass index, sex, marital status, education, income, alcohol consumption, smoking, and cardiometabolic parameters.
CONCLUSIONSerum UA is significantly associated with type 2 diabetes diagnosed using HbA1c levels, independent of other cardiometabolic parameters.