A Primary Investigation on Serum CTX-II Changes in Patients Infected with Brucellosis in Qinghai Plateau, China.
- Author:
Zhi Jun ZHAO
1
;
Qiang LI
1
;
Xin ZHOU
1
;
Li MA
1
;
Li Qing XU
1
;
Pei Zhen YANG
1
;
Xian Ya MENG
1
;
Hui Zhen YU
1
;
Xiao Qing XU
1
;
Jian Ying CAO
1
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Brucellosis; blood; epidemiology; China; epidemiology; Collagen Type II; blood; genetics; Female; Gene Expression Regulation; immunology; Humans; Male; Middle Aged; Peptide Fragments; blood; genetics; Sex Factors
- From: Biomedical and Environmental Sciences 2016;29(3):229-232
- CountryChina
- Language:English
- Abstract: Brucellosis is one of the most widespread zoonotic diseases, with the most frequent complication being osteoarticular changes. The aim of this study was to assess the changes of C-terminal telopeptide of type II collagen (CTX-II) in patients infected with brucellosis. A total of 84 brucellosis patients and 43 volunteers were selected and divided into brucellosis vs. control groups. Serum samples were subjected to serological tests for brucellosis, and CTX-II levels in all samples were measured simultaneously with ELISA. The results showed that serum CTX-II levels in human brucellosis were higher than those of healthy controls, without a statistically significant difference, but serum CTX-II levels in male patients were significantly higher than those of female patients (P<0.05). This finding could indicate the biological changes in the cartilage and bone in human brucellosis.
