Norovirus Infection and Histo-blood Group Antigens in Children Hospitalized with Diarrhea in Lulong and Chenzhou in China.
- Author:
Xiao Man SUN
1
,
2
;
Xiao Feng3 YAN
3
;
Zhi Gang HE
4
;
Jing Xin LI
1
;
Ni Jun GUO
1
;
Zi Qian XU
1
;
Miao JIN
1
;
Dan Di LI
1
;
Yong Kang ZHOU
1
;
Guang Cheng XIE
1
;
Li Li PANG
1
;
Qing ZHANG
1
;
Na LIU
1
;
Zhao Jun DUAN
1
;
Author Information
- Publication Type:Letter
- MeSH: Blood Group Antigens; genetics; Caliciviridae Infections; blood; complications; virology; Child, Preschool; China; Cross-Sectional Studies; Diarrhea; blood; etiology; virology; Feces; virology; Gastroenteritis; blood; virology; Genotype; Humans; Infant; Norovirus; physiology
- From: Biomedical and Environmental Sciences 2016;29(4):286-289
- CountryChina
- Language:English
- Abstract: Norovirus (NoV) is a pathogen that commonly causes viral diarrhea in children. Studies indicate that NoV recognizes human histo-blood group antigens (HBGAs) as cell attachment factors. In order to explore the correlation between of NoV infection and HBGAs, a cross-sectional study was conducted in children less than five years old who were hospitalized with diarrhea in two areas of China between November 2014 and February 2015. Of the paired stool and saliva samples taken from 424 children, NoV was detected in 24 (6%) children, with viral genotypes GII.3 (n=5), GII.4 (n=14), GII.12 (n=1), and GII.17 (n=4). All of the individuals having NoV infection were either secretors (Lea-b+/Lex-y+) or partial secretors (Lea+b+/Lex+y+) except one GII.3 infection of a non-secretor (Lea+b-/Lex+y-). These results suggest that secretor positive is associated with NoV infection, although non-secretors are not absolutely protected from NoV infection.
