Toxic Effects of Tetrabromobisphenol A on Thyroid Hormones in SD Rats and the Derived-reference Dose.

Yan YANG; Wei Wei NI; Lin YU; Ze CAI; Yun Jiang YU

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Toxic Effects of Tetrabromobisphenol A on Thyroid Hormones in SD Rats and the Derived-reference Dose.

Author: Yan YANG ¹ ; Wei Wei NI ² ; Lin YU ³ ; Ze CAI ⁴ ; Yun Jiang YU ³
Author Information

1. Jiangsu Collaborative Innovation Center of Photovoltaic Science and Engineering, Changzhou 213164, Jiangsu, China.
2. School of Environmental & Safety Engineering, Changzhou University, Changzhou 213164, Jiangsu, China.
3. South China Institute of Environmental Sciences, MEP, Guangzhou 510655, Guangdong, China.
4. School of Environmental Science & Engineering, Changan University, Xi'an 710054, Shaanxi, China.
Publication Type:Letter
MeSH: Animals; Dose-Response Relationship, Drug; Female; Male; Polybrominated Biphenyls; toxicity; Rats; Rats, Sprague-Dawley; Thyroid Hormones; metabolism; Thyrotropin; metabolism; Thyroxine; metabolism; Triiodothyronine; metabolism
From: Biomedical and Environmental Sciences 2016;29(4):295-299
CountryChina
Language:English
Abstract: The present study determined the thyroid hormone interference of tetrabromobisphenol A (TBBPA) in Sprague-Dawley (SD) rats, and the derived-reference dose (RfD) of different endpoint effects on mammals based on experimental results and data collection. Based on repeated exposure toxicity tests on mammals and extensive research, the present study used BMDS240 Software to derive a benchmark dose, and analyzed the accuracy and uncertainty, and similarity with other studies. Test results on triiodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH) demonstrated that all the indicators presented a non-monotonous dose-effect relationship clearly, except TSH in male rats exposed to 0-1000 mg/kg BW per day. Therefore, RfDs were derived from different critical effects. In summary, RfD for mammals in the present study was found to be 0.6 mg/kg per day.