Effects of Exogenous Carbon Monoxide Releasing Molecules on the Development of Zebrafish Embryos and Larvae.
- Author:
Jing E SONG
1
;
Jing SI
2
;
Rong ZHOU
2
;
Hua Peng LIU
3
;
Zhen Guo WANG
1
;
Lu GAN
2
;
Fang GUI
4
;
Bin LIU
1
;
Hong ZHANG
2
;
Author Information
- Publication Type:Letter
- MeSH: Animals; Carbon Monoxide; pharmacology; Cardiotonic Agents; toxicity; Dose-Response Relationship, Drug; Embryo, Nonmammalian; drug effects; Embryonic Development; drug effects; Organometallic Compounds; toxicity; Zebrafish; embryology; metabolism
- From: Biomedical and Environmental Sciences 2016;29(6):453-456
- CountryChina
- Language:English
- Abstract: The use of exogenous carbon monoxide releasing molecules (CORMs) provides promise for clinical application; however, the hazard potential of CORMs in vivo remains poorly understood. The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to 400 μmol/L during 4-144 h post fertilization. Toxicity endpoints of mortality, spontaneous movement, heart rate, hatching rate, malformation, body length, and larval behavior were measured. CORM-3 disrupted the progression of zebrafish larval development at concentrations exceeding 50 μmol/L, resulting in embryonic developmental toxicity.
