Relationship between heat stress protein 70 gene polymorphisms and the risk of acute mountain sickness.
- Author:
Fang-Ze LI
1
;
Fang ZHOU
;
Chang-Zheng JIANG
;
Su-Yong SUN
;
Mei-An HE
;
Shu-Yu ZHANG
;
Rong LIAO
;
Hua-Song ZENG
;
Yi-Ming WU
;
Tang-Chun WU
Author Information
- Publication Type:Journal Article
- MeSH: Acute Disease; Adolescent; Adult; Altitude; Altitude Sickness; epidemiology; genetics; Genotype; HSP70 Heat-Shock Proteins; genetics; Humans; Male; Polymorphism, Genetic; Young Adult
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2004;22(6):413-415
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between heat stress proteins 70 (HSPs70) gene polymorphism and the risk of acute mountain sickness.
METHODSFifty-six soldiers with acute mountain sickness and 173 soldiers without that were chosen as cases and controls. HSP70-1, HSP70-2 genotypes were analyzed by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.
RESULTSThe HSP70-1 polymorphism was similar in two groups. The genotype frequency of HSP70-2 B/B in acute mountain sickness group (23.2%) was significantly higher than that in the control (6.9%, P < 0.05, OR = 4.02).
CONCLUSIONThere is a significantly increased association of HSP70-2 B/B genotype with the risk of acute mountain sickness. Individuals with HSP70-2 B/B genotype may have weaker adaptive ability than those without this genotype under altitude stress. The results contribute to provide scientific bases for finding these individuals in specified occupational people, ensuring their health and enhancing work efficiency.
