Relationship of plasma nitric oxide concentration and the activity of nitric oxide synthase with coronary heart disease.
- Author:
Feng WANG
1
;
Chao GAO
;
Mei-An HE
;
Chang-Zheng JIANG
;
Miao YANG
;
Li-Yun ZHANG
;
Tang-Chun WU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Aged, 80 and over; Case-Control Studies; Coronary Disease; blood; Female; Humans; Male; Middle Aged; Multivariate Analysis; Nitric Oxide; blood; Nitric Oxide Synthase; blood; Plasma; metabolism
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2004;22(6):419-421
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the levels of nitric oxide synthase (NOS) and nitric oxide (NO) in patients with coronary heart disease (CHD), and the factors affecting them.
METHODSConcentrations of NO and the activities of NOS in plasma in 136 patients and 206 controls using the corresponding Kits were measured. The data were analyzed using covariance and multiple linear regression analysis with SAS 8.1.
RESULTSThe levels of NO [(217.05 +/- 153.31) micromol/L] and NOS [(14.09 +/- 7.14) U/ml] in patients were significantly higher than that in the healthy controls [(140.69 +/- 90.96) micromol/L, (7.75 +/- 3.79) U/ml, respectively, P < 0.01]. Smoking and drinking were the independent risk factors for NOS, while sex was the independent risk factor for NO (P < 0.01).
CONCLUSIONSThe levels of plasma NO and NOS are closely related with coronary heart disease.
