Inhibitory effect of grape procyanidin on the cell apoptosis induced by radiation.
- Author:
Hai-Zhen LIU
1
;
Jin-Yi ZHONG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Apoptosis; drug effects; radiation effects; Biflavonoids; pharmacology; Catechin; pharmacology; Cell Proliferation; Mice; Mice, Inbred Strains; Pancreas; cytology; drug effects; radiation effects; Proanthocyanidins; pharmacology; Proto-Oncogene Proteins; metabolism; Proto-Oncogene Proteins c-bcl-2; Vitis; chemistry; bcl-2-Associated X Protein; metabolism
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2004;22(6):448-451
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the inhibition effect of grape procyanidin (GPC) on the cell apoptosis and injury of proliferation induced by radiation.
METHODSThree indices including apoptosis rate, proliferation rate and expression of bcl-2 and bax protein were examined in the mice pancreas after taking different dose GPC by mouth and radiation by (60)Co-gamma ray once.
RESULTSThe cell proliferation and bcl-2 expression in high dose GPC group (3.16% +/- 0.13% and 49.8% respectively), were higher than those in radiation control group (0.64% +/- 0.11%, 29.7%), but the cell apoptosis rate and bax expression (19.8% and 55.0% respectively), were lower than those in radiation control group (35.6%, 85.7%). All the above differences were statistically significant (P < 0.05).
CONCLUSIONGPC has certain protective effect against the mice pancreatic cell apoptosis and the abnormal expression of bcl-2 and bax protein induced by (60)Co-gamma.
