Effects of beta-cypermethrin on voltage-gated potassium channels in rat hippocampal CA3 neurons.
- Author:
Zhi-Yan FU
1
;
Chun-Yun DU
;
Yang YAO
;
Chao-Wei LIU
;
Yu-Tao TIAN
;
Bing-Jun HE
;
Tao ZHANG
;
Zhuo YANG
Author Information
1. College of Medicine, Nankai University, Tianjin 300071, China.
- Publication Type:Journal Article
- MeSH:
Animals;
CA3 Region, Hippocampal;
cytology;
physiology;
Cells, Cultured;
Female;
Insecticides;
toxicity;
Male;
Neurons;
cytology;
drug effects;
physiology;
Patch-Clamp Techniques;
Potassium Channels, Voltage-Gated;
drug effects;
physiology;
Pyrethrins;
toxicity;
Rats;
Rats, Wistar
- From:
Acta Physiologica Sinica
2007;59(1):63-70
- CountryChina
- Language:Chinese
-
Abstract:
The effects of beta-cypermethrin (consisting of alpha-cypermethrin and theta-cypermethrin) on the transient outward potassium current (I(A)) and delayed rectifier potassium current (I(K)) in freshly dissociated hippocampal CA3 neurons of rats were studied using whole-cell patch-clamp technique. The results indicated that alpha-cypermethrin increased the value of I(A) and theta-cypermethrin decreased the value of I(A), though both of them shifted steady activation curve of I(A) towards negative potential. theta-cypermethrin contributed to the inactivation of I(A). The results also showed that alpha-cypermethrin and theta-cypermethrin decreased the value of I(K), and shifted the steady state activation curve of I(K) towards negative potential. Both alpha-cypermethrin and theta-cypermethrin had no obvious effects on the inactivation of I(K). theta-cypermethrin prolonged recovery process of I(K). These results imply that both transient outward potassium channels and delayed rectified potassium channels are the targets of beta-cypermethrin, which may explain the mechanism of toxical effects of beta-cypermethrin on mammalian neurons.
