A comparison of postoperative emergence agitation between sevoflurane and thiopental anesthesia induction in pediatric patients.
10.4097/kjae.2015.68.4.373
- Author:
Ji Seon SON
1
;
Eunjoo JANG
;
Min Wook OH
;
Ji Hye LEE
;
Young Jin HAN
;
Seonghoon KO
Author Information
1. Department of Anesthesiology and Pain Medicine, Chonbuk National University Medical School and Hospital, Jeonju, Korea. shko@jbnu.ac.kr
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords:
Agitation;
Pediatrics;
Sevoflurane;
Thiopental
- MeSH:
Anesthesia*;
Anesthesia, Intravenous;
Child;
Delirium;
Dihydroergotamine*;
Double-Blind Method;
Humans;
Incidence;
Inhalation;
Nitrous Oxide;
Pediatrics;
Propofol;
Prospective Studies;
Thiopental*
- From:Korean Journal of Anesthesiology
2015;68(4):373-378
- CountryRepublic of Korea
- Language:English
-
Abstract:
BACKGROUND: This study was performed to compare the incidence of emergence agitation (EA) between inhalation and intravenous anesthesia induction in children after sevoflurane anesthesia. METHODS: In this prospective and double-blind study, 100 children aged 3 to 7 years were enrolled. Subjects were randomly assigned to the sevoflurane (Group S) or thiopental (Group T) anesthesia induction groups. Anesthesia was induced using 8% sevoflurane and 4-6 mg/kg thiopental in Groups S and T, respectively. Anesthesia was maintained with nitrous oxide and sevoflurane. The children were evaluated at 5 and 20 min after arrival in the postanesthesia care unit (PACU) with a four-point agitation scale and the Pediatric Anesthesia Emergence Delirium scale. The incidence of EA and administration of the rescue agent were recorded. RESULTS: The incidence of EA was significantly lower in Group T compared to Group S at 5 min after PACU arrival (3/49 patients, 6% vs. 12/47 patients, 26%, P = 0.019). However, there was no difference between the two groups at 20 min after PACU arrival (23/49 vs. 19/47 patients in Group T vs. Group S, P = 0.425). The overall incidence of EA was 60% (28/47 patients) in Group S and 41% (20/49 patients) in Group T (P = 0.102). The number of children who received propofol as a rescue agent was significantly lower in Group T (Group S: 14/47 vs. Group T: 5/49, P = 0.031). CONCLUSIONS: Intravenous anesthesia induction with thiopental reduced the incidence of EA in the early PACU period compared to inhalation induction with sevoflurane in 3- to 7-year-old children undergoing sevoflurane anesthesia.
