Regulation of pancreatic beta-cell function by adipocytes.
- Author:
Yu-Feng ZHAO
1
;
Chen CHEN
Author Information
1. Endocrine Cell Biology, Prince Henry's Institute of Medical Research, Melbourne, VIC 3168, Australia.
- Publication Type:Journal Article
- MeSH:
Adipocytes;
physiology;
Adiponectin;
physiology;
Animals;
Diabetes Mellitus, Type 2;
physiopathology;
Glucose;
metabolism;
Humans;
Insulin;
pharmacology;
Insulin-Secreting Cells;
physiology;
Leptin;
physiology;
Lipid Metabolism
- From:
Acta Physiologica Sinica
2007;59(3):247-252
- CountryChina
- Language:English
-
Abstract:
Adipokines, the bioactive factors derived mainly from adipocytes, regulate pancreatic beta-cell function including insulin secretion, gene expression and apoptosis. In this review, we propose that adipokines influence beta-cell function through three interdependent pathways. The first is through regulating lipid and glucose metabolism in beta-cells. The second implicates the change of ion channel opening and closing in beta-cells. The third pathway is via the modification of insulin sensitivity of beta-cells. The endocrine function of adipocytes is dynamic, and the secretion of various adipokines changes under different metabolic conditions. During the progression from the normal state to obesity and to type 2 diabetes, adipokines contribute to the occurrence and development of beta-cell dysfunction in type 2 diabetes.
