Synthesis and antibacterial, antifungal properties of 5-(5-nitro-2-furfuryliden)-imidazolidin -2,4-dion and derivative
- Author:
Dat Quang Nguyen
- Publication Type:Journal Article
- Keywords:
drug
- MeSH:
Pharmaceutical Preparations;
Anti-Bacterial Agents;
Antifungal Agents
- From:Pharmaceutical Journal
1999;274(2):14-16
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Nitration of furfural gave 5-nitro furfural diacetat (NFD). By the condensation of NFD with imidazolidin -2,4-dion, derivative I was formed. Compound I underwent Mannich reaction and gave II-V with formaldehyd (36% aqueous solution) and various amines. The structure of synthesized compounds were characterized by UV and IR. The obtained products were tested for biological activities such as antibacterial and antifungal. All synthesized compounds showed a high antibacterial activity on 8 strains of bacteria and a high antifungal activity against Candida albicans. Among these, derivative I showed the highest activity.
