Preparation of isopsoralen loaded nanostructured carrier and its in vitro transdermal permeation characteristics.
10.19540/j.cnki.cjcmm.20170507.001
- Author:
Jian-Yun PANG
1
;
Xiao LIU
1
;
Bao-de SHEN
2
;
Cheng-Ying SHEN
2
;
Wang-Quan LIAN
2
;
Juan LIU
1
;
Chun-Xiao HU
1
;
Rui-Na ZHONG
1
;
Run-Chun XU
1
;
Hai-Long YUAN
2
Author Information
1. College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China.
2. Department of Pharmacy, Air Force General Hospital, PLA, Beijing 100142, China.
- Publication Type:Journal Article
- Keywords:
in vitro transdermal permeation;
nanostructured lipid carrier;
skin retention;
isopsoralen
- From:
China Journal of Chinese Materia Medica
2017;42(13):2473-2478
- CountryChina
- Language:Chinese
-
Abstract:
To increase the permeation and retention of isopsoralen in skin, and improve its bioavailability.Isopsoralen loaded nanostructure liquid carrier (IPRN-NLC) was prepared by high pressure homogenization andoptimized by orthogonal experiment with the encapsulation efficiency, drug loading and average particle size as the evaluation indexes. The in vitro transdermal permeation of IPRN-NLC was evaluated by Franze diffusion cells.The results showed that solid-liquid lipid ratio of optimum IPRN-NLC formulation was 7∶3,drug-lipid ratio of 1∶30, 1% surfactant. Under these conditions, IPRN-NLC had an average encapsulation of （90.25±0.73）%,drug loading of （1.56±0.27）% and an average particle size of (305±1.57) nm.The in vitro transdermal permeation results showed that IPRN-NLC could increase the amount of IPRN permeated though skin, with 3 times of the epidermal retention as compared with IPRN solution. From the results we can know that the IPRN-NLC prepared by high pressure homogenization can improve the permeation andaccumulation of IPRN in the skin, with wide application prospects in the field of transdermal administration.
