The influence of tumor cells spreading in blood to relapse and distant metastasis of hepatocellular carcinoma after surgery.
- Author:
Yang LIU
1
;
Guo-tong ZHANG
;
Meng-chao WU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Carcinoma, Hepatocellular; blood; pathology; surgery; Female; Follow-Up Studies; Humans; Liver Neoplasms; blood; pathology; surgery; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Neoplastic Cells, Circulating; Postoperative Period; RNA, Messenger; blood; alpha-Fetoproteins; genetics; metabolism
- From: Chinese Journal of Surgery 2008;46(20):1583-1585
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the relationship between peripheral blood hepatocellular carcinoma cells-associated AFP mRNA and tumor relapse and metastasis.
METHODSTo detect several blood samples from the HCC patients by nested RT-PCR to find out AFP mRNA after 24 h, 72 h and one week and 4 weeks after surgery, and followed up the HCC patients for 1, 2, 3 years.
RESULTSThere were 7 patients occurred relapse or distant metastasis in 12 patients with AFP mRNA positive (7/12, 58.3%), there were 5 patients occurred relapse in 19 patients with AFP mRNA negative (5/19, 26.3%) within 1 year, there was 4 patients occurred relapse in second year (9/19, 47.3%); 5 patients occurred relapse in third year (10/19, 52.6%). Obvious connection between patients AFP mRNA positive and AFP mRNA negative was observed (P < 0.01).
CONCLUSIONSHCC with AFP mRNA positive has more change to be recurrent compared with HCC patients with AFP mRNA negative.
