Vitamin D receptor gene polymorphisms: no association with low bone mineral density in adolescent idiopathic scoliosis girls.
- Author:
Wen-jun CHEN
1
;
Yong QIU
;
Feng ZHU
;
Ze-zhang ZHU
;
Xu SUN
;
Zhen LIU
;
Zhi-jun CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Bone Density; genetics; Child; Female; Genotype; Humans; Polymorphism, Genetic; Receptors, Calcitriol; genetics; Scoliosis; genetics; physiopathology
- From: Chinese Journal of Surgery 2008;46(15):1183-1186
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of vitamin D receptor (VDR) gene polymorphisms with low bone mineral density (BMD) in adolescent idiopathic scoliosis (AIS) girls.
METHODSBlood samples were obtained from 146 AIS girls and 146 healthy girls. Anthropometric parameters of AIS group including age, body height, weight and Cobb angle were all recorded. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect and analyze VDR gene distributions of AIS group and control group. BMD of the lumbar spine (L(1)-L(4)) and proximal femur were measured using dual energy x-ray absorptiometry in AIS group.
RESULTSThe frequency of Bb genotype was significantly higher in patients than that in controls (P < 0.05). There was no distinction among the lumbar spine and proximal femur BMD of each genotype in AIS group (P > 0.05).
CONCLUSIONVDR gene polymorphisms have no association with the low spine lumbar and proximal femur BMD in AIS girls.
