Relation between Anemia and Vulnerable Coronary Plaque Components in Patients with Acute Coronary Syndrome: Virtual Histology-Intravascular Ultrasound Analysis.
10.3346/jkms.2012.27.4.370
- Author:
Young Joon HONG
1
;
Myung Ho JEONG
;
Yun Ha CHOI
;
Jin A SONG
;
Dong Han KIM
;
Ki Hong LEE
;
Futoshi YAMANAKA
;
Min Goo LEE
;
Keun Ho PARK
;
Doo Sun SIM
;
Nam Sik YOON
;
Hyun Ju YOON
;
Kye Hun KIM
;
Hyung Wook PARK
;
Ju Han KIM
;
Youngkeun AHN
;
Jeong Gwan CHO
;
Jong Chun PARK
;
Jung Chaee KANG
Author Information
1. Heart Research Center, Chonnam National University Hospital, Gwangju, Korea. myungho@chollian.net
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Acute Coronary Syndrome;
Plaque;
Anemia;
Intravascular Ultrasound
- MeSH:
Acute Coronary Syndrome/complications/*pathology/ultrasonography;
Aged;
Albuminuria/urine;
Anemia/complications/*diagnosis;
C-Reactive Protein/analysis;
Coronary Angiography;
Creatinine/blood;
Diabetes Complications;
Female;
Hemoglobins/analysis;
Humans;
Male;
Middle Aged;
Necrosis/pathology;
Odds Ratio;
Plaque, Atherosclerotic/*ultrasonography;
Predictive Value of Tests;
*Ultrasonography, Interventional
- From:Journal of Korean Medical Science
2012;27(4):370-376
- CountryRepublic of Korea
- Language:English
-
Abstract:
The aim of the present study was to evaluate the plaque components and the predictors of thin-cap fibroatheroma (TCFA) in anemic patients with acute coronary syndrome using virtual histology-intravascular ultrasound (VH-IVUS). Anemia was defined according to criteria of the World Health Organization, (i.e. , hemoglobin levels < 13 g/dL in men and < 12 g/dL in women) and we compared VH-IVUS findings between anemia group (171 patients, 260 lesions) and non-anemia group (569 patients, 881 lesions). Anemia group had greater % necrotic core (NC) volume (21% +/- 9% vs 19% +/- 9%, P = 0.001) compared with non-anemia group. Hemoglobin level correlated negatively with absolute NC volume (r = -0.235, P < 0.001) and %NC volume (r = -0.209, P < 0.001). Independent predictors of TCFA by multivariate analysis were diabetes mellitus (odds ratio [OR], 2.213; 95% confidence interval [CI], 1.403-3.612, P = 0.006), high-sensitivity C-reactive protein (OR, 1.143; 95% CI, 1.058-1.304, P = 0.012), microalbuminuria (albumin levels of 30 to 300 mg/g of creatinine) (OR, 2.124; 95% CI, 1.041-3.214, P = 0.018), and anemia (OR: 2.112; 95% CI 1.022-3.208, P = 0.028). VH-IVUS analysis demonstrates that anemia at the time of clinical presentation is associated with vulnerable plaque component in patients with acute coronary syndrome.
