The role of human herpesvirus-8 infection in the pathogenesis of multiple myeloma.
- Author:
Chun-Yang ZHANG
1
Author Information
1. Department of Hematology, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China.
- Publication Type:Journal Article
- MeSH:
Cytokines;
biosynthesis;
Dendritic Cells;
metabolism;
virology;
Herpesviridae Infections;
complications;
epidemiology;
virology;
Herpesvirus 8, Human;
immunology;
physiology;
Humans;
Multiple Myeloma;
complications;
metabolism;
virology;
Seroepidemiologic Studies
- From:
Journal of Experimental Hematology
2002;10(1):81-84
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma is a B-cell neoplasm characterized by abnormal proliferation and accumulation of monoclonal plasma cells in the bone marrow. Recently some laboratories have detected human herpesvirus-8 (HHV-8) DNA sequences in bone marrow dendritic cells from myeloma patients. It has been suggested that the cytokines expressed by HHV-8 gene, such as vIRF, vIL-8R and vIL-6, may play a role in the pathogenesis of multiple myeloma. However, the majority of European investigators failed to find evidence to confirm this observation. It remains unclear whether HHV-8 is consequentially associated with myeloma or only a regional opportunistic infection. Controversy still focuses on the role of specific HHV-8 strains involved in pathogenesis of multiple myeloma and causality between the
