Association of the relationship between HLA-DQB1 alleles and major beta-thalassemia in 42 guangdong Chinese.
- Author:
Rong BAO
1
;
Chun CHEN
;
Jian-Pei FANG
;
Shao-Liang HUANG
Author Information
1. Lingnan Cord Blood Bank, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou 510120, China.
- Publication Type:Journal Article
- MeSH:
Alleles;
Asian Continental Ancestry Group;
genetics;
Female;
Gene Frequency;
Genetic Predisposition to Disease;
HLA-DQ Antigens;
genetics;
HLA-DQ beta-Chains;
Humans;
Male;
beta-Thalassemia;
genetics
- From:
Journal of Experimental Hematology
2002;10(1):87-88
- CountryChina
- Language:Chinese
-
Abstract:
To investigate the relationship between HLA-DQB1* alleles and major beta-thalassemia, the HLA-DQB1* loci typing was performed with polymerase chain reaction-sequence specific primer (PCR-SSP) in 42 unrelated (unconsanguineous) patients with major beta-thalassemia and 45 normal control individuals in Guangdong Province. Results showed that the frequency of HLA-DQB1*06 allele in patient group (19.0%) was higher than that in the control group (4.4%) kappa(2) = 8.961, p < 0.01). Our data suggests that HLA-DQB1*06 allele is associated with pathogenesis of the major beta-thalassemia in Guangdong area.
