GVHD Following Autologous Peripheral Blood Stem Cell Trasplantation Reduced Malignancy Relapse
- Author:
Da-Si GUO
1
;
Xiao-Lin LI
;
Su ZHANG
;
Jie FU
;
Yang YANG
;
Yue YIN
Author Information
1. The Fourth People Hospital of Xuzhou of Jiangsu Prouince, Xuzhou 221009, China.
- Publication Type:Journal Article
- From:
Journal of Experimental Hematology
2001;9(3):287-288
- CountryChina
- Language:Chinese
-
Abstract:
Administration of the immunosuppressive drug cyclosporine (CSA) after autologous peripheral blood stem cell transplantation (APBSCT) induces a systemic auto-immune syndrome resembling graft-versus-host disease (GVHD), this syndrome termed autologous GVHD has significant antitumor activity, it can reduce the incidence of tumor relapse after APBSCT. The antitumor effect of this auto-aggression syndrome can be enhanced by the administration of gamma-interferon (gamma-IFN). Five consecutive patients who received APBSCT received therapy inducing autologous GVHD. Intravenous administration of CSA [1 mg/(kg.d) for 28 days] was begin on the day of transplantation. gamma-interferon (0.025 mg/m(2) qod) was administered sub-cutaneously from days 7 throngh 28 after transplatation. Results showed that four of five occured autologous GVHD-skin demage, five in control didn't occur autologous GVHD. The relapse rate of the treated cases was 20% (1/5) versus 60% (3/5) of the control, and the median survival time of the treated cases was 20 (4 - 30) months versus 10 (2 - 20) months of the control. The data indicates that autologous GVHD results in low relapse rate of the patients rececving APBSCT.
