Effects of electroacupuncture on learning and memory ability and glial cells of the hippocampus in the rat of Alzheimer disease.
- Author:
Shu-xiu ZHU
1
;
Guo-jie SUN
Author Information
- Publication Type:Journal Article
- MeSH: Alzheimer Disease; physiopathology; therapy; Animals; Disease Models, Animal; Electroacupuncture; Female; Hippocampus; cytology; physiopathology; Humans; Learning; Male; Memory; Neuroglia; physiology; Random Allocation; Rats; Rats, Sprague-Dawley
- From: Chinese Acupuncture & Moxibustion 2009;29(2):133-136
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study on the mechanism of electroacupuncture for treatment of Alzheimer disease (AD).
METHODSSD rats were randomly divided into a normal group, a sham operation group, a model group and an electroacupuncture group, 12 rats in each group. The AD rat model was prepared by microinjection of amyloid-beta protein (Abeta1-40) into the Meynert nucleus. In the electroacupuncture group, electroacupuncture was given at "Baihui" (GV 20), "Taixi" (KI 3), "Zusanli" (ST 36). The learning and memory ability was assessed by Morris water maze and the glial cell activity in the hippocampus was determined by immunohistochemistry.
RESULTSCompared with the normal group, the glial cell in the hippocampus was activated with increase of the number, and the learning and memory ability reduced in the model group (P < 0.01). After treatment, as compared with the model group, the number of the activated glial cells was reduced and the learning and memory ability was improved in the electroacupuncture group (P < 0.01).
CONCLUSIONElectroacupuncture treatment can decrease the number of activated glial cells so as to protect the neurons, improving the learning and memory ability in the AD rat.
