Prevention and treatment of HBV reinfection following liver transplantation.
- Author:
Guiyu YUAN
1
;
Yili DUAN
;
Fengshui WANG
;
Shuren LIANG
;
Limin ZHU
Author Information
- Publication Type:Clinical Trial
- MeSH: 2-Aminopurine; analogs & derivatives; therapeutic use; Adult; Antiviral Agents; Biopsy; methods; DNA, Viral; analysis; Drug Combinations; Female; Hepatitis B; prevention & control; Hepatitis B Surface Antigens; blood; Hepatitis B e Antigens; blood; Humans; Immunoglobulins; therapeutic use; Lamivudine; therapeutic use; Liver Transplantation; adverse effects; Male; Middle Aged; Postoperative Care; methods; Preoperative Care; methods; Recurrence
- From: Chinese Journal of Hepatology 2002;10(1):14-16
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the prevention and treatment of HBV reinfection after liver transplantation.
METHODSTotal 19 cases of chronic fulminant hepatitis B, the end-stage of liver cirrhosis and liver carcinoma complicated with HBV cirrhosis. Were performed liver transplantation and given anti-viral drugs pre and post transplantation. Famciclovir was administered in 4 cases, lamivudine in 13 cases and lamivudine+HBIG in 2 cases. The serum HBVM and liver biopsy immunohistochemistry were performed.
RESULTSFour cases given famciclovir developed reinfection. Serum HBsAg, HBeAg and HBV DNA were positive in 3 cases. Liver biopsy immunohistochemistry showed HBsAg and HBeAg phenotype. Classical viral hepatitis in 1 case occurred, three cases died. In the lamivudin group 7 cases showed positive for HBsAg, 2 cases positive for HBV DNA, 4 cases HBsAg or HBcAg phenotype. One case showed positive for serum anti-HBc the other negative for HBVM, and liver biopsy immunohistochemistry was negative too.
CONCLUSIONSThese date suggest that anti-virus prevention and treatment in pre and post liver transplantation with HBV infected correlative disease is necessary, feasible and effective.
